Demonstrates nanostructured lipid carriers delivering resveratrol restore coronary artery dilation after acute pressure elevation, suggesting viable vascular drug delivery.
< 0.001), whereas the SIRT-1 inhibitor EX-527 had no effect. RV-NLCs improved the impaired endothelial-dependent dilation of small coronary arteries, following acute pressure elevation, via NO and downstream COX elements, mediated by AMPK. We suggest that RV-NLCs are an effective delivery modality for improved potency and sustained drug release into the vasculature. Our findings have important implications for the future design and implementation of antihypertensive treatment strategies.
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Astley et al. (2021) studied this question.
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