The Risk and Management of Anaphylaxis in the Setting of Immunotherapy

BACKGROUND: Anaphylactic events due to immunotherapy are probably not completely preventable. There is always an inherent risk surrounding the administration of an allergen to an individual who is sensitized to the substance administered. METHODS: There are, however, effective measures to reduce the risk of these events, and to optimize the assurance of a good outcome in the face of such an event. RESULTS: Of prime importance in preventing these episodes is the regular assessment of the patient's health status, especially in regard to asthma, and the careful attention to the prevention of dosing errors. CONCLUSION: Of equal importance, in regard to assuring a good outcome should such an event occur, are the rapid recognition of symptoms and the immediate injection of epinephrine, the drug of choice for the treatment of any episode of anaphylaxis.