Population
Single adult cardiomyocytes and cardiac cell suspension
Design
Preclinical
Authors
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PA may signal hypertrophy in rat cardiomyocytes; leaves open any role in human disease or therapy.
Phosphatidic acid acts as a potential signal transducer for cardiac hypertrophy by increasing intracellular calcium, stimulating protein synthesis, and activating PLC in adult cardiomyocytes.
Dhalla et al. (1997) studied this question.
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