February 13, 2009Biomacromolecules

Quaternary Ammonium β-Cyclodextrin Nanoparticles for Enhancing Doxorubicin Permeability across the In Vitro Blood−Brain Barrier

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Why the study?

Does QAbetaCD nanoparticle delivery improve doxorubicin permeability across an in vitro blood-brain barrier model?

Population

In vitro blood-brain barrier model using bovine brain microvessel endothelial cells (BBMVECs) and U87 cells

Comparison

Quaternary ammonium beta-cyclodextrin… vs Doxorubicin alone and dextran control

Design

Preclinical

Authors

EGEun Seok GilMatrix Engineering (United States)JLJianshu LiChina University of Petroleum, Beijing HXHuining XiaoUniversity of New Brunswick

Discussion

Member takes

Implication

QAbetaCD nanoparticles may aid doxorubicin brain delivery; leaves open translation beyond this in vitro model.

Structured PICO

Does QAbetaCD nanoparticle delivery improve doxorubicin permeability across an in vitro blood-brain barrier model?

Population

In vitro blood-brain barrier model using bovine brain microvessel endothelial cells (BBMVECs) and U87 cells

Intervention

Quaternary ammonium beta-cyclodextrin (QAbetaCD) nanoparticles loaded with doxorubicin (DOX)

Comparator

Doxorubicin alone and dextran control

Outcome

Permeability across the in vitro blood-brain barrier modelsurrogate

QAbetaCD nanoparticles enhance doxorubicin permeability across an in vitro blood-brain barrier model while protecting endothelial cells from cytotoxicity.

Cite This Study

Gil et al. (2009) studied this question.

synapsesocial.com/papers/6a01c3a7897643a80dcb0830 https://doi.org/10.1021/bm801026k

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