Population
Xenopus oocytes expressing Shaker potassium channels
Design
Preclinical
Authors
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Requires cautious interpretation of W434F Shaker mutants in inactivation studies; leaves open translation to native mammalian channels.
The W434F mutation blocks potassium current in Shaker channels by driving them into a predominantly inactivated state.
Yang et al. (1997) studied this question.
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