Copper/Carbon Hybrid Nanozyme: Tuning Catalytic Activity by the Copper State for Antibacterial Therapy

caused membrane damage, lipid peroxidation, and DNA degradation of Gram-negative bacteria, whereas, for Cu-modified copper/carbon nanozymes, the generation of reactive oxygen species (ROS) via peroxidase-like catalytic reactions was the determining factor against both Gram-positive and Gram-negative bacteria. Lastly, we established two bacterially infected animal models, i.e., bacteria-infected enteritis and wound healing, to confirm the antibacterial ability of the copper/carbon nanozymes. Our findings provide a deeper understanding of metal state-dependent enzyme-like and antibacterial activities and highlight a new approach for designing novel and selective antibacterial therapies based on metal-carbon nanozymes.