Why the study?
Does the association between higher LDL-C and risk of myocardial infarction differ across eGFR strata in adults?
Does the association between higher LDL-C and risk of myocardial infarction differ across eGFR strata in adults?
The association between higher LDL-C and risk of myocardial infarction is weaker for people with lower baseline eGFR, suggesting LDL-C may be less useful as a marker of coronary risk among people with CKD than the general population.
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High LDL-C may be weaker MI marker at low eGFR; leaves open eGFR-specific risk thresholds.
Tonelli et al. (2013) studied this question.
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