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Spectrum of autonomous aldosterone secretion in normotension warrants no practice change; leaves open progression to hypertension pending longitudinal data.
=0.001); however, there were no differences in age, aldosterone-to-renin ratio, blood pressure, or renal plasma flow between the 2 groups. These findings indicate a continuum of renin-independent aldosteronism and mineralocorticoid receptor activity in normotension that ranges from subtle to overtly dysregulated and autonomous. Longitudinal studies are needed to determine whether this spectrum of autonomous aldosterone secretion contributes to hypertension and cardiovascular disease.
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Baudrand et al. (2017) studied this question.
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