Answers are grounded in this paper and cite their sources.
Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.
No takes yet. Share an insight, caveat, or question.
He et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: