Oxidized phospholipids in adipose tissue regulate macrophage phenotype and bioenergetics, driving either redox homeostasis in lean states or inflammation in obesity.
phenotype of ATMs isolated from lean mice. Conversely, full-length OxPL species induce proinflammatory gene expression and an activated bioenergetic profile that mimics ATMs isolated from obese mice. Together, these data identify a redox-regulatory Mox macrophage phenotype to be predominant in lean adipose tissue and demonstrate that individual OxPL species that accumulate in adipose tissue instruct ATMs to adapt their phenotype and bioenergetic profile to either maintain redox homeostasis or to promote inflammation.
Serbulea et al. (Mon,) studied this question.