Population
Human embryonic kidney cells expressing hNE/PN1 or hSkM1 sodium channels, and small dorsal root ganglion…
Comparison
Electrophysiological characterization of hNE/PN1… vs hSkM1 (skeletal muscle) sodium channels
Design
Preclinical
Authors
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May amplify DRG excitability via persistent currents; leaves open selective hNE targeting for sensory disorders.
The hNE/PN1 sodium channel exhibits uniquely slow closed-state inactivation, which generates persistent ramp currents that likely boost stimulus depolarizations in sensory neurons.
Cummins et al. (1998) studied this question.
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