March 12, 2004AJP Heart and Circulatory Physiology
Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk
Why the study?
Does a history of preeclampsia impair endothelial function in postpartum women?
Population
50 healthy women, including 16 with prior preeclampsia in their first pregnancy, 14 with a prior…
Comparison
History of preeclampsia in first pregnancy vs History of normotensive pregnancy or never…
Design
Cross-sectional
Follow-up
6-12 months postpartum
Authors
Discussion
Loading...
Member takes
Implication
Impaired endothelial function may persist after preeclampsia; leaves open its role in long-term CV risk.
Structured PICO
Does a history of preeclampsia impair endothelial function in postpartum women?
P
Population
50 healthy women, including 16 with prior preeclampsia in their first pregnancy (evaluated 6-12 months postpartum), 14 with a prior normotensive pregnancy (evaluated 6-12 months postpartum), and 20 never pregnant controls.
I
Intervention
History of preeclampsia in first pregnancy
C
Comparator
History of normotensive pregnancy or never pregnant
O
Outcome
Endothelial function assessed by stress-induced forearm blood flow (FBF) percent change over baseline during a mental stress testsurrogate
Women with a history of preeclampsia exhibit impaired endothelial function up to 1 year postpartum, providing a potential mechanistic explanation for their increased long-term cardiovascular risk.
Cite This Study
Agatisa et al. (2004) studied this question.