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May 1, 1998Genes & DevelopmentOpen Access

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

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Authors

NBNathan BucaySan Francisco VA Medical CenterISIldiko SarosiSemmelweis UniversityCDColin R. DunstanThe University of Sydney

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Implication

Mouse knockout study reveals severe osteoporosis and arterial calcification in osteoprotegerin-deficient mice, indicating a shared molecular pathway between bone loss and vascular disease.

Key Points

  • To determine the in vivo physiological role of osteoprotegerin in regulating postnatal bone mass and skeletal integrity.
  • Generated an osteoprotegerin-deficient (OPG-/-) mouse knockout model.
  • Evaluated bone density, trabecular and cortical architecture, skull morphology, and vascular pathology in adolescent and adult mice.
  • OPG-/- mice exhibited profound reductions in total bone density characterized by severe trabecular and cortical porosity, parietal bone thinning, and high fracture rates.
  • Knockout animals unexpectedly developed extensive medial calcification within the aorta and renal arteries.

Cite This Study

Bucay et al. (1998) studied this question.

synapsesocial.com/papers/6a01f339897643a80dcb2107https://doi.org/10.1101/gad.12.9.1260
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