Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD‐1 via Tumor Immune Microenvironment Remodelling

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cytotoxic T lymphocytes and natural killer (NK) cells at tumor site. The large quantitatively generated reactive oxygen species (ROS) also promoted the polarization of M2-type macrophage to M1-type as well. Benefitting from this tumor immune microenvironment remodelling effect, remarkable malignant orthotopic osteosarcoma therapy efficacy is achieved employing CNO@CuMS + αPD-1 combination strategy under ultrasonic treatment, with no significant side effects are observed. This research not only proposes a method to fabricate high proformance carbon nitride-based nanocatalyst but also provides a new strategy to realize highly efficient malignant bone tumor therapy during clinical practice.