Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

Yan Lan; Mahmoud Moustafa; Maximilian Knoll; Chunxiao Xu; Jennifer Furkel; Adam S. Lazorchak; Tsz-Lun Yeung; Sayed-Mohammad Hasheminasab; Molly H. Jenkins; Sarah Meister; Huakui Yu; Julian Schlegel; Bo Marelli; Zili Tang; Guozhong Qin; Carmen Klein; Jin Qi; Cheng Zhou; George Locke; Damir Krunic; Melissa G. Derner; Christian Schwager; Rachel E. Fontana; Katharina Kriegsmann; Feng Jiang; Katrin Rein; Mark Kriegsmann; Jürgen Debus; Kin-Ming Lo; Amir Abdollahi

doi:10.1016/j.ccell.2021.08.008

Abstract

endothelium and the M2/lipofibroblast-like cell compartment by BA attenuated late-stage RT-induced lung fibrosis. Together, the results suggest that the BART combination has the potential to eradicate therapy-resistant tumors while sparing normal tissue, further supporting its clinical translation.

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Lan et al. (2021) studied this question.

synapsesocial.com/papers/6a023b1dc358352e67dcf446 https://doi.org/10.1016/j.ccell.2021.08.008

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Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

Abstract

Discussion

Cite This Study

Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

Abstract

Discussion

Cite This Study

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