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BACKGROUND: flux between mitochondria and the endoplasmic reticulum (ER). METHODS: homeostasis, mitochondrial-ER linkage and the activity of the main ROS production site, the mitochondrial respiration chain, in an in vitro aging model based on porcine aortic endothelial cells (PAECs), using high-resolution live cell imaging, proteomics and various molecular biological methods. RESULTS: overload exclusively in senescent cells. CONCLUSION: communications we have advanced the understanding of endothelial aging and highlighted a potential basis to develop drugs specifically targeting senescent cells.
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Madreiter‐Sokolowski et al. (2018) studied this question.
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