Why the study?
Epicardial adipose tissue contributes to coronary artery disease, but the relations between its lipoprotein lipase activity, regulators, and ceramides in patients with CAD remained to be evaluated.
Is there an association between lipoprotein lipase (LPL) activity and ceramide content in the epicardial adipose tissue of patients with coronary artery disease?
Population
25 CAD patients undergoing coronary bypass graft and 14 patients without CAD
Comparison
CAD patients vs patients without CAD, and EAT vs SAT
Design
Observational comparative tissue study
Authors
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Association in CAD epicardial fat is hypothesis-generating; leaves open causal role of LPL-ceramide pathway in atherosclerosis.
Is there an association between lipoprotein lipase (LPL) activity and ceramide content in the epicardial adipose tissue of patients with coronary artery disease?
The study identifies a link between lipoprotein lipase activity and atherogenic ceramides in epicardial adipose tissue, suggesting a mechanism for its proinflammatory expansion in coronary artery disease.
Barchuk et al. (2022) studied this question.