Review reveals how phytochemicals target NRF2 signaling and epigenetic mechanisms in oxidative stress diseases, highlighting pathways for targeted therapeutic strategies.
expression and its downstream targets in the nucleus, including HO-1, SOD, and CAT; (2) regulating NRF2 signaling by various kinases like GSK3beta, PI3/AKT, and MAPK; and (3) modifying epigenetic modulation, such as methylation, at the NRF2 promoter region; however, further investigation into other upstream signaling molecules like NRF2 and the effect of phytochemicals on them still need to be investigated in the near future.
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Thiruvengadam et al. (2021) studied this question.
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