Departments of Toxicology and Pathology, University of Uppsala, Uppsala, Sweden (Received 19 January 1976) To explain the diabetogenic action of streptozotocin it is necessary to decide whether it is taken up by the pancreatic islet beta cells. This question, however, still seems to be controversial since there have been reports on studies in rats (Karunanayake, Hearse & Mellows, 1974), dogs and toadfish (Ryo, Beierwaltes, Feehan & Ice, 1974), which indicate that streptozotocin is not accumulated in the pancreatic islets, while other studies in mice (Anderson, Schein, McMenamin & Cooney, 1974) and rats (Karunanayake, Hearse & Mellows, 1975) indicate that such an accumulation in the islet tissue takes place. In this investigation the distribution of labelled streptozotocin in mice was studied by whole body and microautoradiography and an uptake was found in the islets. Methyl-[14C] streptozotocin (sp. act. 11·8 μCi/mg) was obtained from the Monsanto Research Corporation, Dayton, Ohio. Adult C57-B1-mice,
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Tjälve et al. (1976) studied this question.