May 5, 2005European Journal Of Haematology

Early detection of cardiac dysfunction in thalassemic patients by radionuclide angiography and heart rate variability analysis

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Why the study?

Do radionuclide angiography and heart rate variability analysis detect early cardiac dysfunction in asymptomatic patients with beta-thalassemia?

Population

20 patients with beta-thalassemia with no symptoms or echocardiographic evidence of dysfunction at routine…

Design

Cohort

Follow-up

21 months [5,27]

Authors

BCBenedetta De ChiaraAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda WCWilma CrivellaroIstituto di Fisiologia Clinica RSRoberto Sara

Discussion

Member takes

Implication

May flag subclinical LV impairment in asymptomatic beta-thalassemia; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Do radionuclide angiography and heart rate variability analysis detect early cardiac dysfunction in asymptomatic patients with beta-thalassemia?

Population

20 patients (7 females; median 25 yr [first quartile 22, third quartile 28]) with beta-thalassemia with no symptoms or echocardiographic evidence of dysfunction at routine monitoring.

Intervention

Radionuclide angiography (RNA) at rest and during low-dose dobutamine infusion (5-10 gamma/kg/min) and 24-hour Holter monitoring for heart rate variability (HRV) assessment.

Outcome

Early myocardial damage assessed by right and left ventricular ejection fractions (EF) and heart rate variability (HRV).surrogate

Right ventricular dysfunction on radionuclide angiography and abnormal heart rate variability may serve as early markers of cardiac disease in asymptomatic thalassemic patients.

Cite This Study

Chiara et al. (2005) studied this question.

synapsesocial.com/papers/6a02a5f4f1675f581a754b33 https://doi.org/10.1111/j.1600-0609.2005.00434.x

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May 5, 2005European Journal Of Haematology

Early detection of cardiac dysfunction in thalassemic patients by radionuclide angiography and heart rate variability analysis

View Full Paper

Ask AI

Bookmark

Why the study?

Do radionuclide angiography and heart rate variability analysis detect early cardiac dysfunction in asymptomatic patients with beta-thalassemia?

Population

20 patients with beta-thalassemia with no symptoms or echocardiographic evidence of dysfunction at routine…

Design

Cohort

Follow-up

21 months [5,27]

Authors

BCBenedetta De ChiaraAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda WCWilma CrivellaroIstituto di Fisiologia Clinica RSRoberto Sara

Discussion

Member takes

Implication

May flag subclinical LV impairment in asymptomatic beta-thalassemia; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Do radionuclide angiography and heart rate variability analysis detect early cardiac dysfunction in asymptomatic patients with beta-thalassemia?

Population

20 patients (7 females; median 25 yr [first quartile 22, third quartile 28]) with beta-thalassemia with no symptoms or echocardiographic evidence of dysfunction at routine monitoring.

Intervention

Radionuclide angiography (RNA) at rest and during low-dose dobutamine infusion (5-10 gamma/kg/min) and 24-hour Holter monitoring for heart rate variability (HRV) assessment.

Outcome

Early myocardial damage assessed by right and left ventricular ejection fractions (EF) and heart rate variability (HRV).surrogate

Right ventricular dysfunction on radionuclide angiography and abnormal heart rate variability may serve as early markers of cardiac disease in asymptomatic thalassemic patients.

Cite This Study

Chiara et al. (2005) studied this question.

synapsesocial.com/papers/6a02a5f4f1675f581a754b33 https://doi.org/10.1111/j.1600-0609.2005.00434.x

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

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