Does continuous intracoronary thermodilution reveal microvascular dysfunction in patients with Type II Diabetes Mellitus compared to non-diabetic patients?
Continuous intracoronary thermodilution identifies impaired CFR and MRR in diabetic patients with non-obstructive coronary arteries, highlighting subclinical microvascular and diastolic dysfunction.
Compared with non-diabetic patients, CFR and MRR were lower in patients with DM and non-obstructive epicardial coronary arteries, while both resting and hyperemic coronary flow and resistance were similar. LASr was lower in diabetic patients, confirming the presence of a subclinical diastolic dysfunction associated to the microcirculatory impairment. Continuous intracoronary thermodilution-derived indexes provide a reliable and operator-independent assessment of coronary macro- and microvasculature and might potentially facilitate widespread clinical adoption of invasive physiologic assessment of suspected microvascular disease.
Gallinoro et al. (Tue,) studied this question.