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Shows how tachykinin 1 neurons signal negative outcomes in reward scenarios, suggesting specific neuronal roles.
neurons show little modulation to other task-related events and are only weakly driven by aversive stimuli. Together, these data demonstrate that Tac1 marks a subpopulation of LHb neurons that encodes valence-biased prediction errors, preferentially responding to worse-than-expected outcomes in appetitive contexts. Our results provide insight into cell-type-specific contributions of habenular neurons in nRPE signaling and enable more targeted manipulations to understand their role in reward-guided behavior.
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Suzuki et al. (2026) studied this question.
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