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May 9, 2026Journal of Agricultural and Food Chemistry

Linear Peptidomimetics Containing Isoxazoline Scaffold: Design, Synthesis, Bioevaluation as Efficient Insecticidal Agents

Junkun Ren Zhigang Zhang Liqiao Shi Hexiang Wang Y Wang Ruoheng Jin Wei Fang Quanjie Xia Xinsheng Wang Longzhu Bao Tong Long Yan Gong Ling Zhao Shaoyong Ke

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Key Points

This research aims to design and evaluate isoxazoline-containing peptidomimetics as insecticidal agents against lepidopteran larvae.
Synthesis of linear peptidomimetics containing isoxazoline scaffold.
Bioevaluation against L0 and L1 larvae for insecticidal activity.
Computational studies using density functional theory and molecular docking to analyze binding affinity to the GABA receptor.
Achieved 100% mortality against L0 and L1 larvae at 0.195 μg/mL.
Demonstrated higher activity compared to Chlorantraniliprole.
Strong binding affinity to the GABA receptor indicated by molecular docking studies.

Implication

Demonstrates high insecticidal activity in lepidopteran pests, indicating novel pest management options.

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Cite This Study

Ren et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2b9ce8c8c81e964044f https://doi.org/10.1021/acs.jafc.5c16699

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