Demonstrates enhanced stability and release of cannabinoids in alginate microparticles, suggesting improved oral delivery methods.
) achieved high EE% (CBD 78.8 ± 0.9%; THC 46.5 ± 0.5% for CA-MPs) and high total cannabinoid content (up to 21.36% w/w). MPs exhibited monodisperse size distributions (PDI < 0.01). Stability tests demonstrated significant cannabinoid protection, although light exposure caused some degradation, especially for THC. Chitosan or pectin coatings increased particle size and modulated drug release, resulting in a three-phase pH-dependent profile with delayed release compared to uncoated MPs. Overall, alginate MPs with biopolymer coatings represent a promising oral delivery platform to enhance the stability and therapeutic efficacy of cannabis bioactives.
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Cosenza et al. (2026) studied this question.
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