Population
In vitro model using active norovirus RNA-dependent RNA polymerase, homopolymeric templates, and synthetic…
Design
Preclinical
Authors
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Animal data warrant no clinical changes; leaves open human validation of replication mechanisms.
The study proposes a novel model for norovirus genome replication initiation, involving VPg-protein-primed initiation for polyadenylated genomic RNA and de novo initiation for antigenomic RNA.
Rohayem et al. (2006) studied this question.
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