BACKGROUND: F]-FDG-PET has been investigated as a potential imaging standard in ambiguous cases, with arterial spin-labeling (ASL) MRI gaining recent interest. PURPOSE: F]-FDG-PET. DATA SOURCES: A systematic search of PubMed, Scopus, and Embase was conducted until March 13, 2024. STUDY SELECTION: F]-FDG-PET, and presence of sufficient diagnostic performance data. Exclusion criteria were meeting abstracts, comments, summaries, protocols, letters and guidelines, longitudinal studies, and overlapping cohorts. DATA ANALYSIS: F]-FDG-PET and ASL MRI were calculated, and a summary receiver operating characteristic curve was plotted. DATA SYNTHESIS: F]-FDG-PET. LIMITATIONS: The number of studies was relatively small, with a small sample size. The studies used different scanning protocols as well as a mix of diagnostic metrics, all of which might have introduced heterogeneity in the data. CONCLUSIONS: F]-FDG-PET in the diagnosis of FTD, it exhibited a decent diagnostic performance to justify its further investigation as a quicker and more convenient alternative.
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