Why the study?
Does exposure to complications during pregnancy increase the risk of premature acute coronary syndrome in adult offspring?
Does exposure to complications during pregnancy increase the risk of premature acute coronary syndrome in adult offspring?
Maternal complications during pregnancy are associated with a significantly increased risk of premature acute coronary syndrome in adult offspring.
Should not yet alter offspring CVD risk assessment; leaves open confirmation of intergenerational ACS links in prospective studies.
OBJECTIVE: To investigate the association between complications during pregnancy and premature coronary heart disease in adult offspring. METHODS: We conducted a population-based case-control study of 153 Indonesian patients with a first acute coronary syndrome (ACS) (age ≤55 years) and 153 age-matched and sex-matched controls. Data on complications during pregnancy (high blood pressure, preterm delivery) and maternal infections in pregnancy were obtained, together with sociodemographic data, clinical profiles, laboratory measurements and adulthood cardiovascular disease (CVD) risk factors at hospital admission or enrolment. Conditional logistic regression was performed to assess the association between overall pregnancy complications, and specific groupings of complications and premature ACS. RESULTS: 5.2, 1.1 to 24.2, p=0.035) were associated with offspring ACS. CONCLUSIONS: Offspring of mothers with complications during pregnancy have an increased risk for premature ACS in adulthood, which may be of particular relevance in populations in transition, where the incidence of both pregnancy-related morbidity and CVD are high.
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Qanitha et al. (2017) studied this question.
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