Why the study?
Does edoxaban affect routine coagulation assays and can anti-Xa assays estimate its concentration in plasma samples from healthy subjects?
Does edoxaban affect routine coagulation assays and can anti-Xa assays estimate its concentration in plasma samples from healthy subjects?
Edoxaban variably affects routine coagulation assays depending on the reagent, but chromogenic anti-Xa assays can reliably measure its plasma concentration up to 500 µg/L.
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Clinicians should avoid routine assays to monitor edoxaban; leaves open anti-Xa assay utility in patients.
Hillarp et al. (2018) studied this question.
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