January 1, 2004Thrombosis and Haemostasis

Local INR calibration of the Owren type prothrombin assay greatly improves the intra- and interlaboratory variation

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Why the study?

Does local INR calibration using two calibrant plasmas improve the precision of the Owren PT assay in hospital and primary care laboratories?

Population

Laboratories in hospitals and primary health care units that perform the Owren PT assay in Sweden

Comparison

Local calibration by means of only two… vs Previous calibration procedure (prior to 1999)

Design

Other

Follow-up

3 years

Authors

NENils EgbergUppsala University GNGunnar NordinUppsala University LSLennart StigendalSahlgrenska University Hospital

Discussion

Member takes

Implication

May support local INR calibration to improve hospital lab precision; leaves open primary care adoption and outcome impact.

Structured PICO

Does local INR calibration using two calibrant plasmas improve the precision of the Owren PT assay in hospital and primary care laboratories?

Population

Laboratories in hospitals (n=88 in 2002) and primary health care units (n=246 in 2002) that perform the Owren PT assay in Sweden

Intervention

Local calibration by means of only two lyophilised national plasma calibrators and expression of results as an international normalized ratio (INR)

Comparator

Previous calibration procedure (prior to 1999)

Outcome

Interlaboratory and intralaboratory variation (coefficient of variation)surrogate

A simplified local INR calibration procedure using two calibrant plasmas significantly improves the precision of the Owren PT assay across both hospital and primary care laboratories.

Cite This Study

Egberg et al. (2004) studied this question.

synapsesocial.com/papers/6a030fa0200d7a04bd75568b https://doi.org/10.1160/th03-07-0419

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