April 13, 2017Journal of Lipid ResearchOpen Access

Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids

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Population

Fasted mice, including models with induced genetic LPL deletion and genetic loss of CD36

Design

Preclinical

Authors

DSDiego ScerboUniversity of Iowa NSNi-Huiping SonNew York University ASAlaa SirwiKing Abdulaziz University

Discussion

Member takes

Implication

Challenges LPL/CD36 dependence of fasting kidney lipid accumulation in animals; leaves open alternative uptake pathways for study.

Structured PICO

Population

Fasted mice, including models with induced genetic LPL deletion and genetic loss of CD36

Intervention

Inhibition of LPL with poloxamer 407, induced genetic LPL deletion, or genetic loss of CD36

Outcome

Kidney triglyceride accumulation and fatty acid uptakesurrogate

Fasting-induced triglyceride accumulation in the kidney correlates with plasma non-esterified fatty acids but is independent of lipoprotein lipid uptake and the CD36 transporter.

Cite This Study

Scerbo et al. (2017) studied this question.

synapsesocial.com/papers/6a03314da3a0c1863b651964 https://doi.org/10.1194/jlr.m074427

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