Self-Gating: An Adaptive Center-of-Mass Approach for Respiratory Gating in PET

F-FDG patient scans were included in this paper. An external device-based signal was used as the gold standard, and the correlation coefficient of the data-driven signal with the device-based signal was measured. Our method successfully extracted respiratory signal from 30 out of 31 datasets. The failure case was due to lack of uptake in the field of view. Moreover, our sign determination method obtained correct results for all scans excluding the failure case. Quantitatively, the proposed signal extraction approach achieved a median correlation of 0.85 with the device-based signal. Gated images using optimized data-driven signal showed improved lesion contrast over static image and were comparable to those using device-based signal. We presented a new data-driven method to automatically extract respiratory motion signal from list-mode PET data by optimizing VOI for COM calculation, as well as determine motion direction from signal asymmetry. Successful application of the proposed method on most clinical datasets and comparison with device-based signal suggests its potential of serving as an alternative to external respiratory monitors.