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September 15, 1998CirculationOpen Access

Abciximab (ReoPro, Chimeric 7E3 Fab) Demonstrates Equivalent Affinity and Functional Blockade of Glycoprotein IIb/IIIa and α v β 3 Integrins

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Key result

Abciximab binds GP IIb/IIIa and αvβ3 with equal affinity, dynamically redistributing between both integrins.

Why the study?

Abciximab was initially developed to block GP IIb/IIIa receptors on platelets but also binds with equivalent affinity to alpha(v)beta3 integrins, warranting detailed characterization of this interaction.

Comparison

Binding affinity and functional blockade of GP IIb/IIIa versus alpha(v)beta3 integrins by abciximab

Design

In vitro characterization study

Authors

STSusan H. TamTransnet (South Africa)PSPatricia M. SassoliReaction Biology Corporation (United States)RJRobert E. JordanThornton Tomasetti (United States)

Discussion

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Implication

Abciximab's dual αvβ3/GPIIb/IIIa blockade may contribute to PCI benefits; leaves open whether αvβ3 adds incremental value.

PICO

I
Intervention / Comparator
Abciximab
O
Primary Outcome
Binding affinity and functional blockade of GP IIb/IIIa and αvβ3 integrins

Cite This Study

Tam et al. (1998) studied this question. Abciximab was evaluated on Binding affinity and functional blockade of GP IIb/IIIa and αvβ3 integrins. Abciximab binds with equivalent affinity to both GP IIb/IIIa and αvβ3 integrins and redistributes between the two receptors in vitro.

synapsesocial.com/papers/6a0341901e37aa8cc46506d7https://doi.org/10.1161/01.cir.98.11.1085

Topics

Dual antiplatelet therapy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.1991 · 361 citations
  2. 2Flow cytometric observations on the in vivo use of Fab fragments of a chimaeric monoclonal antibody to platelet glycoprotein IIb-IIIa1993 · 36 citations
  3. 3Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells1992 · 175 citations
  4. 4Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 31995 · 65 citations
  5. 5Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques.1993 · 645 citations