MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals

Erick C. Castelli; Mateus Vidigal de Castro; Michel Satya Naslavsky; Marília O. Scliar; Nayane dos Santos Brito Silva; Heloisa S. Andrade; Andréia S. Souza; Raphaela Neto Pereira; Camila Ferreira Bannwart Castro; Celso Teixeira Mendes‐Junior; Diogo Meyer; Kelly Nunes; Larissa R. B. Matos; Moníze V. R. Silva; Jaqueline Y. T. Wang; Joyce Esposito; Vivian R. Cória; Raul Hernandes Bortolin; Mário Hiroyuki Hirata; Jhosiene Y. Magawa; Edécio Cunha‐Neto; Verônica Coelho; Keity Souza Santos; Maria Lúcia Carnevale Marin; Jorge Kalil; Miguel Mitne‐Neto; Rui M. B. Maciel; Maria Rita Passos‐Bueno; Mayana Zatz

doi:10.3389/fimmu.2021.742881

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Abstract

associated with symptomatic infections. These variants are related to higher expression of soluble MICA and low expression of MICB. Thus, quantitative differences in these molecules that modulate natural killer (NK) activity could contribute to susceptibility to COVID-19 by downregulating NK cell cytotoxic activity in infected individuals but not in the asymptomatic partners.

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synapsesocial.com/papers/6a0349b0bc3ffe278e656056 https://doi.org/10.3389/fimmu.2021.742881

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MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals

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Abstract

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MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infection in Highly Exposed Individuals

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