Why the study?
The triglyceride-glucose index may serve as a surrogate marker of insulin resistance, but its association with macrovascular and microvascular damage is unclear.
Is the triglyceride-glucose (TyG) index associated with macrovascular and microvascular damage in community-dwelling elderly individuals?
Is the triglyceride-glucose (TyG) index associated with macrovascular and microvascular damage in community-dwelling elderly individuals?
An elevated TyG index is associated with arterial stiffness and nephric microvascular damage, supporting its potential use as a clinical surrogate marker for vascular damage in the elderly.
Answers are grounded in this paper and cite their sources.
Cross-sectional association warrants no practice change; leaves open TyG index as vascular surrogate marker in elderly.
BACKGROUND: It has been reported that the triglyceride-glucose (TyG) index may serve as a simple and credible surrogate marker of insulin resistance (IR). However, its association with macrovascular and microvascular damage is unclear. Accordingly, the objective of the present study is to investigate the association of macrovascular and microvascular damage with the TyG index. METHODS: A total of 2830 elderly participants from the Northern Shanghai Study (NSS) were enrolled. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Parameters of vascular damage, including carotid-femoral pulse wave velocity (cf-PWV), brachial-ankle pulse wave velocity (ba-PWV), ankle-brachial index (ABI), carotid intima-media thickness (CMT), carotid plaque, estimated glomerular filtration rate (eGFR) and the urine albumin-to-creatinine ratio (UACR), were measured and calculated. However, no significant relationship was observed between the TyG index and lower extremity atherosclerosis, carotid hypertrophy or carotid plaque. CONCLUSION: An elevated TyG index was significantly associated with a higher risk of arterial stiffness and nephric microvascular damage. This conclusion lends support to the clinical significance of the TyG index for the assessment of vascular damage.
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Zhao et al. (2019) studied this question.
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