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December 6, 2021Journal of Medicinal ChemistryOpen Access

Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1

Michael J. Boyd Philip N. Collier Michael P. Clark Hongbo Deng Sarathy Kesavan Steven Ronkin Nathan D. Waal Jian Wang Jingrong Cao Pan Li Jon H. Come Ioana Davies John P. Duffy John E. Cochran John J. Court Kishan R. Chandupatla Katrina L. Jackson François Maltais Hardwin O’Dowd Christina Boucher Tony Considine W. P. Taylor Hong Gao Ananthisrinivas Chakilam Juntyma J. Engtrakul Daniel K. Crawford Elizabeth A. Doyle Jonathan A. Phillips Raymond A. Kemper Rebecca Swett James Empfield Mark E. Bunnage Paul S. Charifson Sanjay S. P. Magavi

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Abstract

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is a low-molecular-weight, potent ELOVL1 inhibitor that may serve as a useful tool for exploring therapeutic approaches to the treatment of ALD.

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Boyd et al. (2021) studied this question.

synapsesocial.com/papers/6a036d9ac567d7abdf697415 https://doi.org/10.1021/acs.jmedchem.1c00948

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