Preclinical study reveals novel antigen-presenting cells drive Treg-mediated tolerance to gut microbiota in early life, highlighting parallel pathways between thymic and peripheral immunity.
antigen-presenting cell with an essential function in early life. Our studies reveal parallel pathways for the establishment of tolerance to self and foreign antigens in the thymus and periphery, respectively, marked by the involvement of shared cellular and transcriptional programmes.
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Akagbosu et al. (2022) studied this question.
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