Revision is needed. The proposed structure of 1 for konbamide, a calmodulin antagonist isolated from the sea sponge Theonella sp., must be reconsidered. Both cyclic peptides of structure 1 containing L- and D-bromohydroxytryptophan were synthesized by bromination of the protected cyclic peptide. Their NMR spectra and HPLC traces were found to differ from those of the natural product, although the mass spectra are identical.
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Schmidt et al. (1996) studied this question.