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August 5, 2019Bone ResearchOpen Access

Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice

Jing Xie Jingting Lin Min Wei Yan Teng Qi He Guan Yang Xiao Yang

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Abstract

-deficient mice. Therefore, inhibition of Akt signaling by PTEN is required for the maintenance of articular cartilage. Disrupted Akt signaling in articular chondrocytes triggers oxidative stress-induced chondrocyte senescence and causes OA.

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Xie et al. (2019) studied this question.

synapsesocial.com/papers/6a0386490e829fb7536b3b31 https://doi.org/10.1038/s41413-019-0062-y

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