KCNE2/KCNQ1 K+ channels are essential for gastric acid secretion and maintaining gastric mucosa architecture.
KCNE2/KCNQ1 loss may impair gastric function; leaves open human relevance of cardiac channel modulators.
The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.
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Heitzmann et al. (2007) studied this question.
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