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Clinicians should scrutinize trial design quality before applying results; leaves open empirical testing of planning safeguards in stroke research.
Most errors in clinical trials are a result of poor planning. Fancy statistical methods cannot rescue design flaws. Thus careful planning with clear foresight is crucial. Issues in trial conduct and analyses should be anticipated during trial design and thoughtfully addressed. Fundamental clinical trial design issues are discussed.
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Scott Evans (2010) studied this question.
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