Does an AI model for pulmonary venous hypertension ranking from chest radiography improve correlation with echocardiographic LVDD grading compared to human radiologist staging?
AI-assisted chest X-ray analysis provides more consistent staging of pulmonary venous hypertension correlating with left ventricular diastolic dysfunction than human readers.
Isolated-Left Ventricular Diastolic Dysfunction LVDD ranges (and may progress) from preclinical asymptomatic, symptomatic-LVDD, to LVDD-predominate Heart Failure HF presentations; if recognized early, LVDD progression might be preventable. Current early-HF screening remains limited, providing opportunities for insights from a standard Chest X-Ray CXR. While CXR assessment for "pulmonary congestion" supports suspected-HF evaluation in evidence-based guidelines, the potential for systematic Pulmonary Venous Hypertension PVH-Staging to contribute to initial detection and scaling of LVDD is unclear. This study compared CXR-based PVH-Staging to Doppler Echocardiography DEcho-based LVDD-Grading in the absence of systolic dysfunction. Questions included: (1) With PVH-Staging performed by cardiothoracic radiologists, what intra-/inter-reader variabilities remain? (2) Does PVH-Staging track LVDD-Grading? and (3) Can AI-assisted PVH prediction of LVDD-Grade match human performance? CXR examinations of 1,682 (including 750 asymptomatic/healthy) subjects, without: (1) Anatomical/physiological confounders of DEcho or CXR examinations (≤ 24 h apart), and (2) AI model-training confounders, were independently assigned 1 of 11 (9 PVH-related) Pulmonary Vasculature Patterns PVPs by 4 cardiothoracic radiologists and repeated for reliability evaluation. Expert-consensus Human Ground Truth HGT PVH PVPs were correlated with LVDD Grades (0 to 3-4), as were PVH-Rank predictions by a transformer-based AI model "PVPI". Despite experience-dependent intra-/inter-reader reliability in PVP assignment, there was significant (p < 0.001) overall consistency. With increasing HGT PVH Stage, a significant (p < 0.001) trend towards increasing LVDD Grade was found; while PVH-Staging achieved confidence backing Grade 0/No LVDD, confident LVDD Grade recognition was not achieved until Grades 3-4/Restrictive Filling. However, a significantly (p < 0.001) stronger incrementally positive trend in PVPI PVH-Ranking with LVDD-Grading was demonstrated. Although validated, PVH-Staging for LVDD-Grading is limited by reader variabilities. AI-assisted PVH-Ranking may facilitate earlier and widespread objective CXR screening for LVDD which is ubiquitous in HF.
White et al. (Fri,) studied this question.