Why the study?
Does early treatment with captopril reduce left ventricular dilatation and improve haemodynamic and neuroendocrine profiles in haemodynamically stable patients with acute myocardial infarction?
Population
99 haemodynamically stable patients with acute myocardial infarction, selected on clinical grounds as being…
Comparison
Captopril started between 6 and 24 hours after… vs Identical placebo.
Design
RCT, Randomised, double blind, placebo controlled
Follow-up
12 months
Authors
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Supports early captopril in stable post-MI patients to limit dilatation; confirms ACEI remodeling benefit.
Does early treatment with captopril reduce left ventricular dilatation and improve haemodynamic and neuroendocrine profiles in haemodynamically stable patients with acute myocardial infarction?
Early treatment with captopril after acute myocardial infarction significantly decreases left ventricular dilatation without causing significant hypotension, though it does not improve aerobic exercise capacity.
Ray et al. (1993) studied this question.
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