May 1, 1991AJP Heart and Circulatory Physiology
Physical and physiological determinants of transmitral velocity: numerical analysis
Population
Mathematical formulation for exponential chamber pressure-volume relationships with active ventricular…
Design
Other
Authors
Discussion
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Member takes
Implication
Supports refined mitral inflow interpretation; hypothesis-generating for diastolic assessment pending clinical validation.
Structured PICO
P
Population
Mathematical formulation for exponential chamber pressure-volume relationships with active ventricular relaxation (2,187 combinations investigated)
O
Outcome
Physical and physiological determinants of the transmitral velocity patternsurrogate
A mathematical model demonstrates that transmitral velocity is primarily determined by transmitral pressure difference, net atrioventricular compliance, and mitral valve impedance, offering strategies for better noninvasive assessment of diastolic function.
Cite This Study
Thomas et al. (1991) studied this question.