What question did this study set out to answer?

Determine whether the BRAF V600E mutation serves as an effective biomarker to predict disease progression and relapse in pediatric Langerhans cell histiocytosis.

May 9, 2019Pediatric and Developmental Pathology

BRAF V600E Mutation: A Significant Biomarker for Prediction of Disease Relapse in Pediatric Langerhans Cell Histiocytosis

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Authors

EÖErdener ÖzerUniversity of Copenhagen ASAkin Sevinc DİDilek İnceUniversity of Iowa Hospitals and Clinics

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Implication

Clinical study reveals BRAF V600E mutation predicts relapse in pediatric Langerhans cell histiocytosis, highlighting targeted therapy for multisystem disease.

Key Points

Determine whether the BRAF V600E mutation serves as an effective biomarker to predict disease progression and relapse in pediatric Langerhans cell histiocytosis.
Assessed BRAF V600E mutation status in pediatric patients diagnosed with Langerhans cell histiocytosis.
Evaluated associations between mutation presence, clinical progression, disease relapse, and multisystem involvement.
The BRAF V600E mutation significantly correlates with higher rates of disease progression and relapse in pediatric patients.
Presence of the mutation defines a clear candidate subgroup for targeted molecular therapy among children with relapsed or multisystem disease.

Cite This Study

Özer et al. (2019) studied this question.

synapsesocial.com/papers/6a03c8f2f6c0e004a6de0f22 https://doi.org/10.1177/1093526619847859

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Implication

Clinical study reveals BRAF V600E mutation predicts relapse in pediatric Langerhans cell histiocytosis, highlighting targeted therapy for multisystem disease.

BRAF V600E Mutation: A Significant Biomarker for Prediction of Disease Relapse in Pediatric Langerhans Cell Histiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

BRAF V600E Mutation: A Significant Biomarker for Prediction of Disease Relapse in Pediatric Langerhans Cell Histiocytosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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