In placental mammals, fetal trophoblast cells invade the maternal uterine tissue to invade the placenta. Many conserved molecular players, such as PLAC1, are involved in this process of placentation; however, their mechanistic roles remain unclear. In a new study, Ayelen Moreno-Irusta, Michael J. Soares and colleagues show that PLAC1 has a conserved role in both rat and human placentation, although it acts on species-specific cell populations. To learn more about how this story developed and the people behind it, we spoke to first and corresponding author, Ayelen Moreno-Irusta, as well as corresponding author Michael J. Soares, University Distinguished Professor at the University of Kansas Medical Center, Kansas, USA.
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