MRI reveals significant gender differences in Osgood-Schlatter disease: male patients manifest more severe symptoms with later onset

This study aimed to deepen the understanding of Osgood-Schlatter Disease (OSD) by characterizing MRI findings and comparing differences based on gender and laterality to enhance diagnostic precision and guide treatment. We retrospectively analyzed MRI scans of 81 OSD patients acquired using a Siemens 3.0T scanner. Two experienced radiologists independently evaluated patellar ligament morphology, tibial tuberosity characteristics (including staging), and adjacent tissue alterations. Statistical analyses compared findings based on gender and affected side. Significant differences were observed between male and female patients regarding age at presentation, severity of patellar tendon distortion, and tibial tuberosity staging. Specifically, males presented at a later age with more severe manifestations. In contrast, no significant differences were detected based on the affected side (left vs. right) for any evaluated parameters, including associated findings. Comprehensive MRI analysis reveals distinct gender-related differences in OSD presentation, particularly concerning age, patellar tendon distortion, and tibial tuberosity involvement, with males exhibiting more severe and later-onset disease. These findings contribute valuable insights for the diagnosis and clinical understanding of OSD. No significant laterality differences were identified.