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May 13, 2026Journal of Global Infectious DiseasesOpen Access

Examining the Clinical Efficacy of Novel Beta-Lactam and Beta-Lactamase Inhibitor Antibiotics: A Systematic Review and Meta-Analysis

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Authors

MEMohamed Hamed ElkholiMSMohamed ShoaibZAZeyad Alrais

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Overview

Systematic review shows beta-lactam and beta-lactamase inhibitors improve outcomes in infections, indicating their potential against multidrug resistance.

Key Points

  • To evaluate the clinical efficacy of novel beta-lactam and beta-lactamase inhibitor antibiotics against specific bacterial infections.
  • Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
  • Included trials comparing novel antibiotics with the best available therapy
  • Excluded pediatric, noncomparative, and in vitro studies
  • Calculated odds ratios and confidence intervals using random effects models
  • Assessed risk of bias using the RoB 2 tool.
  • NβL/βLIs showed similar effectiveness to best available therapy (OR 1.12)
  • Trend towards benefit in multidrug resistant infections (OR 1.23)
  • NβL/βLIs were superior for microbiological cure (OR 1.33)
  • Safety outcomes comparable between studied groups.

Cite This Study

Elkholi et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbbe1c527af8f1ecf6cbhttps://doi.org/10.4103/jgid.jgid_133_25
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