Multi-substrate conversion synchronous cofactor-regeneration for efficient natural product biosynthesis

Key Points

• The research aims to enhance the efficiency of natural product biosynthesis by addressing the issues of cofactor regeneration.
• Proposed a multi-substrate conversion approach for efficient cofactor regeneration.
• Analyzed redox cofactors as electron mediators in biosynthesis processes.
• Evaluated the impact of sacrificial agents on atomic economy and by-product generation.
• Demonstrated improved efficiency in the synthesis of natural products.
• Reduced unwanted by-products associated with traditional sacrificial agents.