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One-pot click chemistry achieves high yields of 1,2,3-triazoles in PEG-400, suggesting efficient late-stage functionalization.
A green, one-pot CuAAC using phenylhydrazine HCl as azide surrogate in PEG-400/H 2 O enables safe, chromatography-free synthesis of 1,2,3-triazoles in high yields with broad scope and late-stage functionalization.
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Samad et al. (2026) studied this question.
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