One-pot click chemistry using hydrazine as an azide surrogate: easy access to 1,2,3-triazole functionalities

Key Points

• The research focuses on developing a one-pot synthesis method for 1,2,3-triazoles using click chemistry techniques.
• Utilized phenylhydrazine HCl as an azide surrogate in a one-pot method.
• Carried out synthesis in PEG-400 and water under copper-catalyzed azide-alkyne cycloaddition (CuAAC) conditions.
• Eliminated the need for chromatography in the synthesis process.
• Achieved high yields of 1,2,3-triazoles.
• Demonstrated broad scope for various substrates.
• Facilitated late-stage functionalization of compounds.