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May 13, 2026RSC Applied Interfaces1 citationsOpen Access

Programmable Shrinking and Aggregation of pH-Thermo Dual-Responsive Amphiphilic Polymeric Nanoparticles Governed by Molecular Architecture

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GNGiuseppe NunziataPolitecnico di MilanoMSMattia SponchioniPolitecnico di MilanoFRFilippo RossiPolitecnico di Milano

Key Points

  • The research aims to establish a predictive framework for the behavior of dual-responsive polymeric nanoparticles.
  • Designed amphiphilic polymeric nanoparticles with pH and thermo responsiveness.
  • Analyzed their aggregation and shrinking behaviors in response to different stimuli.
  • Established links between molecular architecture and responsive behavior.
  • Demonstrated that modifications in molecular architecture significantly affect the drug delivery behavior of nanoparticles.
  • Found that dual-responsiveness can be finely tuned through architectural changes.

Abstract

Stimuli-responsive polymeric nanoparticles represent powerful drug delivery systems capable of responding to pathological microenvironments. However, most dual-responsive platforms are treated as binary on/off systems, and a predictive framework linking molecular...

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Cite This Study

Nunziata et al. (2026) studied this question.

synapsesocial.com/papers/6a03cc3d1c527af8f1ed034bhttps://doi.org/10.1039/d6lf00061d
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dual pH- and thermoresponsive nano-objects with tunable morphologies and dye encapsulation prepared via aqueous emulsion polymerization-induced self-assembly2026
  2. 2Fluorescent-Tagged, pH- and Redox-Responsive Polymeric Nanocarrier for Site-Specific Gastrointestinal Delivery2026
  3. 3Monitoring structural change and drug release of responsive nanoparticles using polarity-sensitive fluorophores2025
  4. 4Analysis of Structural Changes of pH–Thermo-Responsive Nanoparticles in Polymeric Hydrogels2024 · 15 citations
  5. 5Synthesis and Acidic pH-Responsive Disassembly of Dual-Location Shell-Sheddable/Core-Degradable Block Copolymer Nanoassemblies and Their Controlled Drug Delivery2026 · 1 citations